At The Kahn Lab, we study the cellular and molecular mechanisms underlying obesity and diabetes
Using molecular biology, mouse genetics, Mass Spectrometry, lipidomics, and RNAseq with validation by gene overexpression and knockdown, we’ve discovered new mechanisms for the regulation of metabolism and immune responses. We always confirm that these mechanisms function to regulate human health and disease. Our work has had a major impact on understanding the critical role of the adipocyte as an endocrine organ and as a metabolic factory, consuming and producing metabolites that have systemic effects on insulin action, energy balance and inflammation.
Our research interests include:
Molecular mechanisms of insulin action and insulin resistance
Molecular pathogenesis of obesity and type 2 diabetes
Glucose transport, regulation of glucose and lipid metabolism
The adipocyte as an endocrine organ
Regulation and biologic effects of fatty acid hydroxy fatty acids
Contact us.
The Barbara Kahn Lab
Division of Endocrinology, Diabetes, and Metabolism
Center for Life Sciences, 7th floor
330 Brookline Ave, Boston, MA 02115